Bacteria has the ability to cause a wide array of disruptions and far-reaching harm to a person’s body – Physiologically, Psychologically, Neurologically, affecting the Nervous System, and, Triggering a Autoimmune Reaction
There is magical bacteria that lives in our gut environment yet our microbiome can get messed up by one of five events: Antibiotics, a bout of gastroenteritis, food poisoning, parasitic infection and high stress. Many people can pinpoint the onset of their gut problems by one of these events.
They help us digest food and absorb nutrients, produce digestive enzymes and nutrients like short chain fatty acids, Vitamin A, B12 BK and Biotin, metabolize lipids, break down cholesterol, improve peristalsis and bowel transit time. These good bacteria manufacture three essential amino acids: tryptophan, phenylalanine and tyrosine – Critical nutrients that are the building blocks of dopamine, serotonin and melatonin (grumpy, anxious and can’t sleep)
Bacteria can consume these nutrients before our body has a chance, contributing to malabsorption and malnutrition. Fat malabsorption can lead to deficiencies of Vitamins A and D which are needed to break down carbohydrates.
Bacteria need B12 and Iron for their survival and these are the two most common deficiencies found in people with SIBO – bacteria also need calcium, magnesium, amino acids and others. Bacteria causing diarrhoea contributes to malabsorption and malnutrition.
Bacteroides 39%, Lactobacillus 25%, Clostridium 20%, Streptococcus 60%, E-Coli 36%, Staphylococcus 13%, Klebsiella Pneumonia 11%, Enterococcus 32%, Proteus Mirabilis 6.5%, Helicobacter Py, Peptostrepococcus, Antinomyces, Citrobacter, Shigella, Salmonella, Methanobrevibacter smithii, Lyme, Candida.
Symptoms may vary from person to person depending on what species of bacteria is overgrown and the level of overgrowth and where the bacteria are located. Different species of bacteria have different behaviour’s.
Most bacteria like to feed on sugar, starches and carbs present in our diet by fermenting them – this leads to the releae of gases like hydrogen and methane. When bacteria are over abundant these can lead to a variety of symptoms.
Hydrogen dominate – IBS, autoimmune disorders. People who have Crohn’s or ulcerative colitis typically present with low levels of methane
Methane dominant – bloating, offensive flatulance, abdominal distention after meals, IBS and constipation – prone to weight gain. People with high levels of methane have lower post-meal serotonin levels – Methanbrevibacter smithii is the most common cause.
Producing both Hydrogen and Methane – both constipation and diarrhoea may present depending on which is the more dominate at any given time.
Toxins from the bacteria or other microbes (like Candida) get into the bloodstream then travel to the brain impairing neurotransmitter production or functions that regulate our moods, thoughts and behaviour. These bacteria may also use the Vagus Nerve (transmits signal to the brain, stomach, heart and lungs.) The Vagus Nerve helps to modulate mood, fear and anxiety.
Clostridium – a bacteria associated with conduct disorders, autism, depression, schizophrenia by altering the neurotransmitters in the brain. They can also inhibit the enzyme called dopamine.
Streptococcus – the infection causing Rheumatic fever has proteins in the cell walls similar to the proteins that exist in various places throughout the body like the heart, brain and joints. The immune system may mistake human tissue for the bacteria’s protein and attack causing inflammation and damage to these tissues. A disorder call PANDA’S which develops in children after an infection which manifests as obsessive- compulsive disorder and tic disorder. Can make the gut too acidic. high levels of L-lactate may indicate a bowel overgrowth of Streptococcus.
Helicobacter Py. – (Causes food poisoning) is implicated in the cause of GERD (acid reflux) It can trigger an auto-immune response – Helicobacter can potentially precipitate overgrowth of other bacteria – and it creates intestinal inflammation.
E-Coli – fragments found in the amyloid plaques of people with Alzheimer’s disease whose brains were examined at autopsy.
Bacteroides – high levels found in people with Alzheimer'(University College London Dementia research group research)
Enterococcus – produces lactic acid – killing off good probiotic bacteria like Bifidobacterium -L-lactate is metabolised in the liver – high levers correlate with cognitive dysfunction such as nervousness, memory loss, forgetfulness, confusion and mind going blank.
Candida – causes depletion of the serotonin and increases levels of histamine keeping the body in stress mode. Candida produces a toxin called acetaldehyde which interacts with serotonin and dopamine creating a very powerful opiate called Tetrahydroisoquinolines, this inhibits overall gut motility. Candida creates inflammation of the gut lining, disrupts the proper functioning of the thyroid gland and releases ammonia which lowers the ph of the gut and weakens the immune system. It can also lead to a deficiency of acetycholine sued by the vagus nerve to initiate the migrating motor complex.
Enterobacteria and Proteus – one of the by-products produced is ammonia. Ammonia is a neurotoxin and when in excess can lead to neuroinflammation, impairment of neurons, brain fog, mental confusion impairment of cognitive functioning and more. High ammonia levels can overload the liver and kidneys and may produce a wide range of symptoms like headaches, irritability, fatigue, diarrhoea and nausea.
Some bacteria produce histamine. High levels can lead to a wide variety of psychological disturbances like OCD, addiction, abnormal fears, brain racing, schizophrenia as well as physical symptoms like hives, itching, weepy eyes, runny nose and more.
Dr Emeran Mayer, a professor of medicine and psychiatry at the University of California, Los Angeles, found that connections between regions of the brain differ depending on what species of bacteria is dominant in a person’s gastrointestinal tract.
Dr Mark Lyte of the Texas Tech University Health Sciences Centre studies how the Microbes have the capacity to manipulate behaviour and mood through altering the neural signals in the vagus nerve, changing taste receptor, producing toxins to make us feel bad and releasing chemicals rewards to make us feel good.
Some Brain remedies:
Supplements and herbs will fail as they cannot target the individual bacteria causing mutation of the remaining bacteria, nor can they pass through the BBB (Blood /Brain/Barrier) where the bacteria can reside